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Did you mean da and edar (6 results)?
The EDA/EDAR/NF-kappaB pathway in non-syndromic tooth agenesis: A genetic perspective.
Gao Y, Jiang X, Wei Z, Long H, Lai W. Gao Y, et al. Front Genet. 2023 Apr 3;14:1168538. doi: 10.3389/fgene.2023.1168538. eCollection 2023. Front Genet. 2023. PMID: 37077539 Free PMC article. Review.
Non-syndromic tooth agenesis (NSTA) is one of the most common dental developmental malformations affected by genetic factors predominantly. Among all 36 candidate genes reported in NSTA individuals, EDA, EDAR, and EDARADD play essential roles in ectodermal organ dev …
Non-syndromic tooth agenesis (NSTA) is one of the most common dental developmental malformations affected by genetic factors predominantly. …
EDA, EDAR, EDARADD and WNT10A allelic variants in patients with ectodermal derivative impairment in the Spanish population.
Martínez-Romero MC, Ballesta-Martínez MJ, López-González V, Sánchez-Soler MJ, Serrano-Antón AT, Barreda-Sánchez M, Rodriguez-Peña L, Martínez-Menchon MT, Frías-Iniesta J, Sánchez-Pedreño P, Carbonell-Meseguer P, Glover-López G, Guillén-Navarro E; GIEDE (Spanish multidisciplinary research group for ectodermal dysplasia). Martínez-Romero MC, et al. Orphanet J Rare Dis. 2019 Dec 3;14(1):281. doi: 10.1186/s13023-019-1251-x. Orphanet J Rare Dis. 2019. PMID: 31796081 Free PMC article.
Among all the patients, 37/51 had variants of EDA, 8/51 had variants of the WNT10A gene, 4/51 had variants of EDAR and 5/51 had variants of EDARADD. ...CONCLUSIONS: This is the only molecular study conducted to date in the Spanish population affected by ED. The E …
Among all the patients, 37/51 had variants of EDA, 8/51 had variants of the WNT10A gene, 4/51 had variants of EDAR and 5/51 ha …
EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKA activation and SNAP23-containing complexes.
Yao Y, Yang R, Zhu J, Schlessinger D, Sima J. Yao Y, et al. Cell Biosci. 2023 Jul 10;13(1):128. doi: 10.1186/s13578-023-01082-8. Cell Biosci. 2023. PMID: 37430358 Free PMC article.
BACKGROUND: Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA signaling in skin appendage formation. ...CONCLUSIONS: Overall, in a novel regulatory mechanism, EDA increases plasma membrane trans …
BACKGROUND: Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its membrane receptor EDAR to trigger EDA …
Missense mutations in EDA and EDAR genes cause dominant syndromic tooth agenesis.
Andreoni F, Sgattoni C, Bencardino D, Simonetti O, Forabosco A, Magnani M. Andreoni F, et al. Mol Genet Genomic Med. 2021 Jan;9(1):e1555. doi: 10.1002/mgg3.1555. Epub 2020 Nov 18. Mol Genet Genomic Med. 2021. PMID: 33205897 Free PMC article.
BACKGROUND: Hypohidrotic ectodermal dysplasia (HED) is the most common form of ectodermal dysplasia and is mainly associated with mutations in the EDA, EDAR, and EDARADD responsible for the development of ectodermal-derived structures. HED displays different modes o …
BACKGROUND: Hypohidrotic ectodermal dysplasia (HED) is the most common form of ectodermal dysplasia and is mainly associated with mutations …
EDA and EDAR expression at different stages of hair follicle development in cashmere goats and effects on expression of related genes.
Wu Z, Wang Y, Han W, Yang K, Hai E, Ma R, Di Z, Shang F, Su R, Wang R, Wang Z, Zhang Y, Li J. Wu Z, et al. Arch Anim Breed. 2020 Dec 10;63(2):461-470. doi: 10.5194/aab-63-461-2020. eCollection 2020. Arch Anim Breed. 2020. PMID: 33473371 Free PMC article.
EDA and EDAR expression in fetal fibroblasts and epithelial cells was interfered with by short hairpin RNA (sh-RNA). ...Moreover, EDA and EDAR play an important role in the formation of embryonic placode (Pc). ...
EDA and EDAR expression in fetal fibroblasts and epithelial cells was interfered with by short hairpin RNA (sh-RNA). ...Moreov …
Signaling involved in hair follicle morphogenesis and development.
Rishikaysh P, Dev K, Diaz D, Qureshi WM, Filip S, Mokry J. Rishikaysh P, et al. Int J Mol Sci. 2014 Jan 22;15(1):1647-70. doi: 10.3390/ijms15011647. Int J Mol Sci. 2014. PMID: 24451143 Free PMC article. Review.
The Wnt pathway is considered to be the master regulator during hair follicle morphogenesis. Wnt signaling proceeds through EDA/EDAR/NF-kappaB signaling. NF-kappaB regulates the Wnt pathway and acts as a signal mediator by upregulating the expression of Shh ligand. …
The Wnt pathway is considered to be the master regulator during hair follicle morphogenesis. Wnt signaling proceeds through EDA/ED …
Ectodysplasin A (EDA) - EDA receptor signalling and its pharmacological modulation.
Kowalczyk-Quintas C, Schneider P. Kowalczyk-Quintas C, et al. Cytokine Growth Factor Rev. 2014 Apr;25(2):195-203. doi: 10.1016/j.cytogfr.2014.01.004. Epub 2014 Jan 23. Cytokine Growth Factor Rev. 2014. PMID: 24508088 Free article. Review.
Deficiencies in the EDA - EDA receptor (EDAR) signalling pathway cause hypohidrotic ectodermal dysplasia (HED). This syndrome is characterized by the absence or malformation of several skin-derived appendages resulting in hypotrychosis, hypodontia, heat-intol …
Deficiencies in the EDA - EDA receptor (EDAR) signalling pathway cause hypohidrotic ectodermal dysplasia (HED). This sy …
Distinct impacts of Eda and Edar loss of function on the mouse dentition.
Charles C, Pantalacci S, Tafforeau P, Headon D, Laudet V, Viriot L. Charles C, et al. PLoS One. 2009;4(4):e4985. doi: 10.1371/journal.pone.0004985. Epub 2009 Apr 2. PLoS One. 2009. PMID: 19340299 Free PMC article.
BACKGROUND: The Eda-A1-Edar signaling pathway is involved in the development of organs with an ectodermal origin, including teeth. ...Despite patchy similarities, our detailed work on cheek teeth in Eda(Ta) and Edar(dl-J) mice show that all dental morp …
BACKGROUND: The Eda-A1-Edar signaling pathway is involved in the development of organs with an ectodermal origin, including te …
Comparative analysis of rare EDAR mutations and tooth agenesis pattern in EDAR- and EDA-associated nonsyndromic oligodontia.
Zhang L, Yu M, Wong SW, Qu H, Cai T, Liu Y, Liu H, Fan Z, Zheng J, Zhou Y, Feng H, Han D. Zhang L, et al. Hum Mutat. 2020 Nov;41(11):1957-1966. doi: 10.1002/humu.24104. Epub 2020 Sep 16. Hum Mutat. 2020. PMID: 32906216
This study investigated EDAR mutations in multiplex nonsyndromic oligodontia and comparatively analyzed the EDAR- and EDA-related tooth agenesis patterns. ...Genotype-phenotype correlation analysis demonstrated that the EDAR-related tooth agenesis patt …
This study investigated EDAR mutations in multiplex nonsyndromic oligodontia and comparatively analyzed the EDAR- and EDA …
Deleterious Variants in WNT10A, EDAR, and EDA Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations.
Parveen A, Khan SA, Mirza MU, Bashir H, Arshad F, Iqbal M, Ahmad W, Wahab A, Fiaz A, Naz S, Ashraf F, Mobeen T, Aziz S, Ahmed SS, Muhammad N, Hassib NF, Mostafa MI, Gaboon NE, Gul R, Khan S, Froeyen M, Shoaib M, Wasif N. Parveen A, et al. Int J Mol Sci. 2019 Oct 24;20(21):5282. doi: 10.3390/ijms20215282. Int J Mol Sci. 2019. PMID: 31652981 Free PMC article.
The characteristic features of hypohidrotic ectodermal dysplasia (HED) comprise of hypodontia/oligodontia, along with hypohidrosis/anhidrosis, and hypotrichosis. Pathogenic variants in EDA, EDAR, EDARADD, and TRAF6, cause the phenotypic expression of HED. Genetic al …
The characteristic features of hypohidrotic ectodermal dysplasia (HED) comprise of hypodontia/oligodontia, along with hypohidrosis/anhidrosi …
227 results